VC Activity Faces Continued Slowdown Amid Resilience in Key Sectors
- Shane Gardner
- Jan 30
- 2 min read
Updated: Mar 22

Continued Slowdown in VC Activity
The U.S. venture capital (VC) industry has been grappling with a slowdown that has persisted for three consecutive years, culminating in 2024. This ongoing trend reveals mixed signals of strength and weakness within an uncertain market, prompting investors to reconsider their strategies moving forward.
High Dealmaking Despite Challenges
Despite the pervasive challenges, levels of VC Activity have remained relatively high, buoyed by significant dry powder reserves—capital that has been raised but not yet deployed. However, the lack of substantial exits raises concerns about the future dynamics of fundraising and deal-making.
Performance of IPOs
There have been indications that some initial public offerings (IPOs) have performed well in 2024, providing notable returns for investors. Successfully executed IPOs could serve as a catalyst, encouraging more companies to consider going public, which may alleviate some pressure on VC firms.
Pivotal Year Ahead
The ongoing impacts relating to the dearth of large exits could signal that 2025 will be a crucial year for venture capital fundraising and deal-making. As stakeholders navigate these challenges, they will need to continually reassess their strategies and adapt to the evolving landscape.
Sector-Specific Developments
The annual JP Morgan Healthcare Conference has fueled significant activity within the healthcare sector. Companies such as Truveta, Tune Therapeutics, and Qventus have successfully secured large investments, underscoring strong interest and innovation within healthcare solutions.
Emerging Technologies
Particular sectors are witnessing remarkable investment interest, especially in artificial intelligence (AI) and biotechnology. For example, Qventus recently attracted $105 million in funding for its healthcare AI platform, demonstrating the sector's growing appeal.
Healthcare-focused Fundraising
In a notable collaboration, Eli Lilly partnered with Andreessen Horowitz to create a $500 million fund focused on biotech investment. This partnership reflects continued institutional interest in healthcare innovation amidst the ongoing challenges faced by the VC sector.
Corporate M&A Activity
Significant mergers and acquisitions are also shaping the landscape. Johnson & Johnson's $14.6 billion acquisition of Intra-Cellular Therapies exemplifies a trend of consolidation within the healthcare market, which may influence overall VC dynamics in the future.
Global Observations
While the primary focus remains on the U.S. VC market, it is essential to consider broader global trends. The rise of investments in AI reflects increasing global commitment, with notable advancements and investment levels seen in countries like the UK.
Conclusion
The U.S. venture capital market is navigating a complex landscape marked by a continued slowdown in activity, yet it showcases pockets of resilience, particularly in healthcare and technology sectors. The positive performance of select IPOs, combined with sustained deal activity and significant reserves of dry powder, may herald potential recovery pathways as firms adapt to the shifting dynamics of the market in 2025. The interplay of caution and opportunity will be critical for stakeholders as they forge ahead in this evolving environment.